Irina Trofimova

Personal information

e-mail irina311@inbox.ru
Work address Laboratory of the cell nucleus structure and dynamics, Biology Research Institute, Saint-Petersburg State University, St. Petersburg, 14th Line of Vasilyevsky Island, 29, liter A, 199178, Russia.

Education & Qualifications

2013 - 2017
Post-Doc of Saint-Petersburg State University, Biology Research Institute, Faculty of Cytology and Histology
2010 - 2013

Head of cytogenetics laboratory of Stem cell bank Pokrovski
2009 - 2013

Research assistant of Laboratory of Prenatal Diagnosis of Congenital and Inherited Diseases of Ott’s Institute of Obstetrics and GynecologyLBCs.

2009 - 2013

Lecturer of the Medical college of Saint-Petersburg State University
2006 - 2009
PhD student of Saint-Petersburg State University, Faculty of Biology and Soil Science (Department of Genetics and biotechnology).
Thesis: Phenomenon of selective staining of heterochromatin regions of metaphase chromosomes of the person by acridine orange flurochrome.
2006
Graduated from Bashkir State University, Faculty of Biology, (Department of Biotechnology) as Specialist in Biology

Current research interests

My current research is focusing on the investigation of a transcriptional activity of non-coding DNA at terminal chromosomal regions, tissue-specific and developmental differences of subtelomeric repeats of a transcription, a structure and a function of the resulting transcripts and the behavior of subtelomere-derived RNA during a mitosis. A subtelomeric tandem repeat PO41 is the most interesting in Galliform species for this purpose due to it's high DNA sequence conservation and a similar chromosomal distribution in Galliform species, which can indicate that it's transcripts have important invariable functions.

cells

Redistribution of PO41 non-coding RNA during the cell cycle in chicken MDCC-MSB1 with 3D reconstructions of anaphase and telophase stages. (Trofimova I. et al., 2014 Molecular cytogenetics).

Major Publications

  1. Trofimova I., Chervyakova D., Krasikova A.
    Transcription of subtelomere tandemly repetitive DNA in chicken embryogenesis. Chromosome Research. 2015.
    DOI: 10.1007/s10577-015-9487-3.
  2. Trofimova I., Popova D., Vasilevskaya E., Krasikova A.
    Non-coding RNA derived from a conservative subtelomeric tandem repeat in chicken and Japanese quail somatic cells. Molecular Cytogenetics, 2014. V. 7:102.- p.1-13.
  3. Trofimova I., Popova D., Chervyakova D., Krasikova A.
    Conservative subtelomeric tandem PO41 repeat is transcribed both in chicken and Japanese quail somatic cells. FEBS-EMBO conference, 2014. V. 281 (Suppl. 1).- p.390.
  4. Baranov V., Kuznetzova T., Pendina A., Efimova O., Fedorova I., Trofimova I.
    Epigenetics mechanisms of normal and pathological development of human./ In the book under edition of Zakiyan S. M., Vlasov V. V., Dementieva of E.V. Epigenetics. Novosibirsk. Publishing house of the Siberian Branch of the Russian Academy of Science, 2012. p. 225-266 (book in Russian).
  5. Kuznetzova T., Enukashvily N., Trofimova I., Gorbunova A., Vashukova E., Baranov V.
    Localisation and transcription of human chromosome 1 pericentromeric heterochromatin in embryonic and extraembryonic tissues. Medical genetics, 2012. V.11. 4 (118). p. 19-24 (article in Russian).
  6. Trofimova I., Evdokimenko E., Kuznetzova T.
    Peculiarity of mitotic activity of chorionic villi cytotrofoblast on the first trimester of pregnancy. Journal of obstetrics and female diseases, 2012. T. LX I. V.3. p.115-122 (article in Russian).
  7. Trofimova I., Lyapunova M., Evdokimenko E., Kuznetzova T.
    Effects of different preatreatments on pericentromeric heterochromatin of chromosomes 1, 9 and 16 staining with Acridine Orange Fluorochrome. Medical genetics, 2012. V.11. 4 (118). p. 50-54 (article in Russian).
  8. Kuznetzova T.V.,Trofimova I., Lyapunova M., Evdokimenko E., Baranov V.
    Phenomenon of selective staining of pericentomeric heterochromatin regions in chromosomes from spontaneously dividing cells by acridine orange flurochrome. Genetika, 2012. V. 48. 4. p. 369-375.
  9. Trofimova I., Solovyov K., Fedorova E., Vasilyev V., Patkin E., Kuznetzova T.
    Peculiarities of spatial position of constitutive heterochromatin regions within the nucleus of extraembrionic and embryonic tissues. Genetics and pathology of person, 9. Tomsk: Printing manufactory. 2011. p. 88-91 (article in Russian).
  10. Trofimova I., Lyapunova M., Zolnerovich E., Kuznetzova T., Baranov V.
    Peculiarities of staining of heterochromatic regions of chromosomes from human chorionic villi. Cytology, 2010. V.52. 8. p.685-686 (article in Russian).
  11. Trofimova I., Zolnerovich E., Mylnikov S., Kuznetzova T.
    Comparative analysis of the proliferative status of cytotrophoblast chorionic villi from physiological and missed abortions. Molecular and biological technologies in medical practice, 13. Novosibirsk: Alpha Vista. 2009. p. 259-264 (article in Russian).