The research work of the group is focused on the organization, function and biogenesis of specialized domains (compartments) in the eukaryotic cell nucleus. Dynamic functional organization of nuclear domains in multicellular organisms is one of the most important areas of molecular cell biology. It is known that the programmed regulation of the eukaryotic genome expression cannot be possible without functional compartmentalization of the cell nucleus. At the same time, all major structural components of the complex cellular organelle - the nucleus - are closely linked to the genome architecture and the realization of genetic information. All of it determines the possibility of a quick response to external stimuli, and the regulation of gene expression. The compartmentalization of the cell nucleus contributes to the correct passing of key intranuclear processes such as transcription, processing and post-transcriptional maturation of nascent transcripts, packaging and transport of the messenger and non-coding RNA, replication, reparation and recombination of DNA. 3D-architecture of the genome in the mitotic and meiotic cells is studied in detail by both the whole-genomic approaches and by super-resolution light and electron microscopy. We also pay a special attention to establish a link between the formation of various nuclear domains and the expression of long non-coding RNA molecules.

Major research areas:

Biology of the cell nucleus

3D genome architecture

Mechanisms of nuclear domains formation

Structure and function of meiotic and mitotic chromosomes

Lampbrush chromosomes in birds, amphibians and fishes

Structure and function of regulatory non-coding RNAs

Architectural non-coding RNAs

Animal cytogenetics and genomics

Interspecies hybrid complexes and mechanisms of their reproduction

Mechanisms of genetic material elimination